Loading
RHOH (Rho-related GTP-binding protein RhoH) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Negative regulator of haematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signalling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.95).
In plain words · RHOH (Rho-related GTP-binding protein RhoH) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
RHOH (Rho-related GTP-binding protein RhoH) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Negative regulator of haematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signalling by mediating recruitment and activation of ZAP70.
No product in this corpus aims at RHOH yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Dallery et al, Oncogene, 1995, "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Source.
Sources: HGNC HGNC:686 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15669 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168421 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: breast cancer 0.52 (GraphQL API, CC0))
Negative regulator of haematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signalling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signalling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Location: Cytoplasm; Cell membrane (UniProt). Locus 4p14 (HGNC).
Query for this target: (TITLE:"RHOH" OR ABSTRACT:"RHOH" OR TITLE:"ras homolog family member H" OR ABSTRACT:"ras homolog family member H" OR TITLE:"Rho-related GTP-binding protein RhoH" OR ABSTRACT:"Rho-related GTP-binding protein RhoH") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RHOH, not a curated reading list.