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RCC2 (regulator of chromosome condensation 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.94, animal model 0.28, genetic association 0.63, somatic mutation 0.23).
In plain words · RCC2 (regulator of chromosome condensation 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
RCC2 (regulator of chromosome condensation 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis.
No product in this corpus aims at RCC2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:30297 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P258 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179051 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organisation of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Location: Nucleus, nucleolus; Nucleus; Cytoplasm, cytoskeleton; Chromosome, centromere (UniProt). Locus 1p36.13 (HGNC).
Query for this target: (TITLE:"RCC2" OR ABSTRACT:"RCC2" OR TITLE:"regulator of chromosome condensation 2" OR ABSTRACT:"regulator of chromosome condensation 2" OR TITLE:"TD-60" OR ABSTRACT:"TD-60") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RCC2, not a curated reading list.