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RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.95, animal model 0.35, genetic association 0.00).
In plain words · RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.
No product in this corpus aims at RBPJ yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1993. Earliest sequence paper UniProt cites for the protein: Amakawa et al, Genomics, 1993, "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Source.
Sources: HGNC HGNC:5724 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06330 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168214 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Location: Nucleus; Cytoplasm (UniProt). Locus 4p15.2 (HGNC).
Query for this target: (TITLE:"RBPJ" OR ABSTRACT:"RBPJ" OR TITLE:"recombination signal binding protein for immunoglobulin kappa J region" OR ABSTRACT:"recombination signal binding protein for immunoglobulin kappa J region" OR TITLE:"Recombining binding protein suppressor of hairless" OR ABSTRACT:"Recombining binding protein suppressor of hairless" OR TITLE:"IGKJRB" OR ABSTRACT:"IGKJRB" OR TITLE:"RBPJK" OR ABSTRACT:"RBPJK" OR TITLE:"KBF2" OR ABSTRACT:"KBF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBPJ, not a curated reading list.
Shares Notch signalling, Open Targets Platform.