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RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.83, animal model 0.32, genetic association 0.66, somatic mutation 0.25). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
No product in this corpus aims at RBFOX1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1998. Earliest sequence paper UniProt cites for the protein: Chen et al, 1998, "Molecular cloning and chromosomal localization of a human brain, heart and skeletal muscle specific RNA binding protein gene homologous to fox-1 in Caenorhabditis elegans". Source.
Sources: HGNC HGNC:18222 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NWB1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078328 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0)); IntOGen RBFOX1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Location: Nucleus; Cytoplasm (UniProt). Locus 16p13.3 (HGNC).
Query for this target: (TITLE:"RBFOX1" OR ABSTRACT:"RBFOX1" OR TITLE:"RNA binding fox-1 homolog 1" OR ABSTRACT:"RNA binding fox-1 homolog 1" OR TITLE:"RNA binding protein fox-1 homolog 1" OR ABSTRACT:"RNA binding protein fox-1 homolog 1" OR TITLE:"A2BP1" OR ABSTRACT:"A2BP1" OR TITLE:"FOX-1" OR ABSTRACT:"FOX-1" OR TITLE:"HRNBP1" OR ABSTRACT:"HRNBP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBFOX1, not a curated reading list.