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RBBP8 (DNA endonuclease RBBP8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ).
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.87, genetic association 0.49, somatic mutation 0.55).
In plain words · RBBP8 (DNA endonuclease RBBP8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
RBBP8 (DNA endonuclease RBBP8) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway.
No product in this corpus aims at RBBP8 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1998. Earliest sequence paper UniProt cites for the protein: Fusco et al, Genomics, 1998, "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Source.
Sources: HGNC HGNC:9891 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99708 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101773 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Location: Nucleus; Chromosome (UniProt). Locus 18q11.2 (HGNC).
Query for this target: (TITLE:"RBBP8" OR ABSTRACT:"RBBP8" OR TITLE:"RB binding protein 8, endonuclease" OR ABSTRACT:"RB binding protein 8, endonuclease" OR TITLE:"DNA endonuclease RBBP8" OR ABSTRACT:"DNA endonuclease RBBP8" OR TITLE:"CtIP" OR ABSTRACT:"CtIP" OR TITLE:"COM1" OR ABSTRACT:"COM1" OR TITLE:"SCKL2" OR ABSTRACT:"SCKL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBBP8, not a curated reading list.