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RBBP7 (Histone-binding protein RBBP7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.76, genetic association 0.24).
In plain words · RBBP7 (Histone-binding protein RBBP7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
RBBP7 (Histone-binding protein RBBP7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.
No product in this corpus aims at RBBP7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1993. Earliest sequence paper UniProt cites for the protein: Nielsen M.S. et al, 1993. Source.
Sources: HGNC HGNC:9890 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16576 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000102054 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).
Query for this target: (TITLE:"RBBP7" OR ABSTRACT:"RBBP7" OR TITLE:"RB binding protein 7, chromatin remodeling factor" OR ABSTRACT:"RB binding protein 7, chromatin remodeling factor" OR TITLE:"Histone-binding protein RBBP7" OR ABSTRACT:"Histone-binding protein RBBP7" OR TITLE:"RbAp46" OR ABSTRACT:"RbAp46") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBBP7, not a curated reading list.