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RASSF6 (Ras association domain-containing protein 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.70).
In plain words · RASSF6 (Ras association domain-containing protein 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
RASSF6 (Ras association domain-containing protein 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein.
No product in this corpus aims at RASSF6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2003. Earliest sequence paper UniProt cites for the protein: Burbee D.G. et al, 2003, "RASSF6, a member of the RASSF family of putative tumor suppressors, is transcriptionally repressed in lung and breast cancers". Source.
Sources: HGNC HGNC:20796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZTQ3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169435 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: prostate cancer 0.53 (GraphQL API, CC0))
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. Locus 4q13.3 (HGNC).
Query for this target: (TITLE:"RASSF6" OR ABSTRACT:"RASSF6" OR TITLE:"Ras association domain family member 6" OR ABSTRACT:"Ras association domain family member 6" OR TITLE:"Ras association domain-containing protein 6" OR ABSTRACT:"Ras association domain-containing protein 6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RASSF6, not a curated reading list.