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RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).
In plain words · RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes.
No product in this corpus aims at RAP1A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1988. Earliest sequence paper UniProt cites for the protein: Pizon et al, Oncogene, 1988, "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Source.
Sources: HGNC HGNC:9855 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62834 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000116473 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signalling and its interaction with PKP3. Location: Cell membrane; Cytoplasm; Cytoplasm, perinuclear region; Cell junction (UniProt). Locus 1p13.2 (HGNC).
Query for this target: (TITLE:"RAP1A" OR ABSTRACT:"RAP1A" OR TITLE:"RAP1A, member of RAS oncogene family" OR ABSTRACT:"RAP1A, member of RAS oncogene family" OR TITLE:"Ras-related protein Rap-1A" OR ABSTRACT:"Ras-related protein Rap-1A" OR TITLE:"KREV-1" OR ABSTRACT:"KREV-1" OR TITLE:"SMGP21" OR ABSTRACT:"SMGP21") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAP1A, not a curated reading list.