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QKI (KH domain-containing RNA-binding protein QKI) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Colorectal cancer and 3 more.
RNA reader protein, which recognises and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.97, genetic association 0.00, somatic mutation 0.82, animal model 0.47). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Melanoma.
In plain words · QKI (KH domain-containing RNA-binding protein QKI) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Colorectal cancer and 3 more.
QKI (KH domain-containing RNA-binding protein QKI) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Colorectal cancer and 3 more.
RNA reader protein, which recognises and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation.
No product in this corpus aims at QKI yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Xia J.-H. et al, 1999, "Molecular cloning of human QUAKING gene". Source.
Sources: HGNC HGNC:21100 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96PU8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112531 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.51, gastric cancer 0.50, melanoma 0.57, skin cancer 0.54, breast cancer 0.56 (GraphQL API, CC0)); IntOGen QKI (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA reader protein, which recognises and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognises and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularisation of pre-mRNAs. Location: Nucleus; Cytoplasm; Cytoplasm, cytosol; Cytoplasm, Stress granule (UniProt). Locus 6q26 (HGNC).
Query for this target: (TITLE:"QKI" OR ABSTRACT:"QKI" OR TITLE:"QKI, KH domain containing RNA binding" OR ABSTRACT:"QKI, KH domain containing RNA binding" OR TITLE:"KH domain-containing RNA-binding protein QKI" OR ABSTRACT:"KH domain-containing RNA-binding protein QKI" OR TITLE:"QK3" OR ABSTRACT:"QK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about QKI, not a curated reading list.