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PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
No product in this corpus aims at PTPN3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1991. Earliest sequence paper UniProt cites for the protein: Yang et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin". Source.
Sources: HGNC HGNC:9655 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P26045 (protein name, function text, keywords and locations (REST API)); IntOGen PTPN3 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Location: Cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 9q31.3 (HGNC).
Query for this target: (TITLE:"PTPN3" OR ABSTRACT:"PTPN3" OR TITLE:"protein tyrosine phosphatase non-receptor type 3" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 3" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 3" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 3" OR TITLE:"PTPH1" OR ABSTRACT:"PTPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN3, not a curated reading list.