Loading
PTPN22 (Tyrosine-protein phosphatase non-receptor type 22) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.74, animal model 0.50, genetic association 0.66).
In plain words · PTPN22 (Tyrosine-protein phosphatase non-receptor type 22) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
PTPN22 (Tyrosine-protein phosphatase non-receptor type 22) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules.
No product in this corpus aims at PTPN22 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1998. Earliest sequence paper UniProt cites for the protein: Liu et al, 1998, "Human protein tyrosine phosphatase (70zpep) homolog". Source.
Sources: HGNC HGNC:9652 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y2R2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000134242 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Acts as a negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Location: Cytoplasm (UniProt). Locus 1p13.2 (HGNC).
Query for this target: (TITLE:"PTPN22" OR ABSTRACT:"PTPN22" OR TITLE:"protein tyrosine phosphatase non-receptor type 22" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 22" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 22" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 22" OR TITLE:"Lyp" OR ABSTRACT:"Lyp" OR TITLE:"Lyp1" OR ABSTRACT:"Lyp1" OR TITLE:"Lyp2" OR ABSTRACT:"Lyp2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN22, not a curated reading list.