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PTPN13 (Tyrosine-protein phosphatase non-receptor type 13) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma, Endometrial cancer and 3 more.
Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreas, Endometrial Carcinoma.
In plain words · PTPN13 (Tyrosine-protein phosphatase non-receptor type 13) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma, Endometrial cancer and 3 more.
PTPN13 (Tyrosine-protein phosphatase non-receptor type 13) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma, Endometrial cancer and 3 more.
Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2.
No product in this corpus aims at PTPN13 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1993. Earliest sequence paper UniProt cites for the protein: Honda et al, Leukemia, 1993, "Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P". Source.
Sources: HGNC HGNC:9646 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12923 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163629 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.54, breast cancer 0.56 (GraphQL API, CC0)); IntOGen PTPN13 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2. Location: Cytoplasm, cytoskeleton; Nucleus; Cell projection, lamellipodium (UniProt). Locus 4q21.3 (HGNC).
Query for this target: (TITLE:"PTPN13" OR ABSTRACT:"PTPN13" OR TITLE:"protein tyrosine phosphatase non-receptor type 13" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 13" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 13" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 13" OR TITLE:"PTP1E" OR ABSTRACT:"PTP1E" OR TITLE:"PTP-BAS" OR ABSTRACT:"PTP-BAS" OR TITLE:"PTPL1" OR ABSTRACT:"PTPL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN13, not a curated reading list.