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PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Crizotinib and Sunitinib.
In plain words · PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2.
No product in this corpus aims at PTPN12 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PTPN12: RNA low tissue specificity; high antibody staining in 20 normal tissues; highest cancer staining testis cancer (10 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PTPN12 tissue; Open Targets ENSG00000127947 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Takekawa et al, Biochem. Biophys. Res. Commun, 1992, "Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase". Source.
Sources: HGNC HGNC:9645 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q05209 (protein name, function text, keywords and locations (REST API)); CIViC gene PTPN12 (1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0))
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Location: Cytoplasm; Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7q11.23 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Appendix, Breast, Cervix, Duodenum, Epididymis, Esophagus, Fallopian tube.
Medium only: lung cancer, skin cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PTPN12" OR ABSTRACT:"PTPN12" OR TITLE:"protein tyrosine phosphatase non-receptor type 12" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 12" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 12" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 12" OR TITLE:"PTPG1" OR ABSTRACT:"PTPG1" OR TITLE:"PTP-PEST" OR ABSTRACT:"PTP-PEST") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN12, not a curated reading list.