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PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.
In plain words · PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
No product in this corpus aims at PTP4A3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PTP4A3: RNA tissue enhanced (heart muscle 517 nTPM, skeletal muscle 565 nTPM); blood lineage group enriched (granulocytes 55 nTPM, monocytes 54 nTPM); no normal tissue stained high; highest cancer staining liver cancer (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PTP4A3 tissue; Open Targets ENSG00000184489 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Dayton M.A. et al, Recept. Signal Transduct, 1997, "Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38". Source.
Sources: HGNC HGNC:9636 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75365 (protein name, function text, keywords and locations (REST API)); CIViC gene PTP4A3 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II. Location: Cell membrane; Early endosome (UniProt). Locus 8q24.3 (HGNC).
RNA: tissue enhanced (heart muscle 517 nTPM, skeletal muscle 565 nTPM), detected in many normal tissues. Blood: group enriched (granulocytes 55 nTPM, monocytes 54 nTPM).
No normal tissue stained high.
Medium only: cervical cancer, endometrial cancer, head and neck cancer, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PTP4A3" OR ABSTRACT:"PTP4A3" OR TITLE:"protein tyrosine phosphatase 4A3" OR ABSTRACT:"protein tyrosine phosphatase 4A3" OR TITLE:"Protein tyrosine phosphatase type IVA 3" OR ABSTRACT:"Protein tyrosine phosphatase type IVA 3" OR TITLE:"PRL-3" OR ABSTRACT:"PRL-3" OR TITLE:"PRL-R" OR ABSTRACT:"PRL-R" OR TITLE:"PRL3" OR ABSTRACT:"PRL3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTP4A3, not a curated reading list.