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PSMD6 (26S proteasome non-ATPase regulatory subunit 6) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.25, clinical 0.99).
In plain words · PSMD6 (26S proteasome non-ATPase regulatory subunit 6) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMD6 (26S proteasome non-ATPase regulatory subunit 6) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
No product in this corpus aims at PSMD6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PSMD6 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PSMD6: RNA tissue enhanced (pancreas 269 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (3 of 3 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PSMD6 tissue; Open Targets ENSG00000163636 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1995, "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:9564 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15008 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163636 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Locus 3p14.1 (HGNC).
RNA: tissue enhanced (pancreas 269 nTPM), detected in all normal tissues.
No normal tissue stained high.
Medium only: carcinoid, glioma, skin cancer, testis cancer.
HPA PSMD6 tissue · HPA PSMD6 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMD6" OR ABSTRACT:"PSMD6" OR TITLE:"proteasome 26S subunit, non-ATPase 6" OR ABSTRACT:"proteasome 26S subunit, non-ATPase 6" OR TITLE:"26S proteasome non-ATPase regulatory subunit 6" OR ABSTRACT:"26S proteasome non-ATPase regulatory subunit 6" OR TITLE:"S10" OR ABSTRACT:"S10" OR TITLE:"p44S10" OR ABSTRACT:"p44S10" OR TITLE:"KIAA0107" OR ABSTRACT:"KIAA0107") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMD6, not a curated reading list.