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PSMD3 (26S proteasome non-ATPase regulatory subunit 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, clinical 0.99).
In plain words · PSMD3 (26S proteasome non-ATPase regulatory subunit 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMD3 (26S proteasome non-ATPase regulatory subunit 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
No product in this corpus aims at PSMD3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PSMD3 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PSMD3: RNA tissue enhanced (skeletal muscle 242 nTPM); high antibody staining in 20 normal tissues; highest cancer staining head and neck cancer (4 of 4 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PSMD3 tissue; Open Targets ENSG00000108344 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Kominami et al, Mol. Biol. Cell, 1997, "Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1". Source.
Sources: HGNC HGNC:9560 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43242 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108344 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Locus 17q21.1 (HGNC).
RNA: tissue enhanced (skeletal muscle 242 nTPM), detected in all normal tissues.
Medium: Appendix, Breast, Bronchus, Colon, Duodenum, Endometrium, Fallopian tube, Kidney.
Medium only: renal cancer.
HPA PSMD3 tissue · HPA PSMD3 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMD3" OR ABSTRACT:"PSMD3" OR TITLE:"proteasome 26S subunit, non-ATPase 3" OR ABSTRACT:"proteasome 26S subunit, non-ATPase 3" OR TITLE:"26S proteasome non-ATPase regulatory subunit 3" OR ABSTRACT:"26S proteasome non-ATPase regulatory subunit 3" OR TITLE:"S3" OR ABSTRACT:"S3" OR TITLE:"P58" OR ABSTRACT:"P58" OR TITLE:"Rpn3" OR ABSTRACT:"Rpn3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMD3, not a curated reading list.