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PSMD11 (26S proteasome non-ATPase regulatory subunit 11) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.88, genetic association 0.17, clinical 0.99).
In plain words · PSMD11 (26S proteasome non-ATPase regulatory subunit 11) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMD11 (26S proteasome non-ATPase regulatory subunit 11) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
No product in this corpus aims at PSMD11 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PSMD11 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PSMD11: RNA low tissue specificity; high antibody staining in 1 normal tissue; highest cancer staining melanoma (4 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PSMD11 tissue; Open Targets ENSG00000108671 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Hoffman et al, FEBS Lett, 1997, "Molecular cloning and expression of subunit 9 of the 26S proteasome". Source.
Sources: HGNC HGNC:9556 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00231 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108671 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Location: Nucleus; Cytoplasm, cytosol (UniProt). Locus 17q11.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bone marrow, Colon, Endometrium, Heart muscle, Kidney, Lung, Placenta, Skin.
Medium only: endometrial cancer, head and neck cancer, renal cancer.
HPA PSMD11 tissue · HPA PSMD11 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMD11" OR ABSTRACT:"PSMD11" OR TITLE:"proteasome 26S subunit, non-ATPase 11" OR ABSTRACT:"proteasome 26S subunit, non-ATPase 11" OR TITLE:"26S proteasome non-ATPase regulatory subunit 11" OR ABSTRACT:"26S proteasome non-ATPase regulatory subunit 11" OR TITLE:"S9" OR ABSTRACT:"S9" OR TITLE:"p44.5" OR ABSTRACT:"p44.5" OR TITLE:"MGC3844" OR ABSTRACT:"MGC3844") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMD11, not a curated reading list.