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PSMC4 (26S proteasome regulatory subunit 6B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.66, genetic association 0.00, clinical 0.99).
In plain words · PSMC4 (26S proteasome regulatory subunit 6B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMC4 (26S proteasome regulatory subunit 6B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
No product in this corpus aims at PSMC4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PSMC4 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PSMC4: RNA low tissue specificity; no normal tissue stained high; highest cancer staining liver cancer (2 of 9 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PSMC4 tissue; Open Targets ENSG00000013275 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Ohana et al, Proc. Natl. Acad. Sci. U.S.A, 1993, "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes". Source.
Sources: HGNC HGNC:9551 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P43686 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000013275 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Location: Cytoplasm; Nucleus (UniProt). Locus 19q13.11-q13.13 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high; medium in Adipose tissue, Adrenal gland, Appendix, Breast, Caudate, Cerebellum and more.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
HPA PSMC4 tissue · HPA PSMC4 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMC4" OR ABSTRACT:"PSMC4" OR TITLE:"proteasome 26S subunit, ATPase 4" OR ABSTRACT:"proteasome 26S subunit, ATPase 4" OR TITLE:"26S proteasome regulatory subunit 6B" OR ABSTRACT:"26S proteasome regulatory subunit 6B" OR TITLE:"TBP7" OR ABSTRACT:"TBP7" OR TITLE:"S6" OR ABSTRACT:"S6" OR TITLE:"MGC8570" OR ABSTRACT:"MGC8570") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMC4, not a curated reading list.