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PSMB9 (Proteasome subunit beta type-9) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, clinical 0.99).
In plain words · PSMB9 (Proteasome subunit beta type-9) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMB9 (Proteasome subunit beta type-9) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
No product in this corpus aims at PSMB9 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSMB9: RNA tissue enhanced (lymphoid tissue 140 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PSMB9 tissue; Open Targets ENSG00000240065 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Kelly et al, Nature, 1991, "Second proteasome-related gene in the human MHC class II region". Source.
Sources: HGNC HGNC:9546 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P28065 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000240065 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: plasma cell myeloma 0.61, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Location: Cytoplasm; Nucleus (UniProt). Locus 6p21.32 (HGNC).
RNA: tissue enhanced (lymphoid tissue 140 nTPM), detected in all normal tissues.
No normal tissue stained high; medium in Appendix, Cervix, Colon, Duodenum, Endometrium, Lung and more.
No cancer stained high; medium in breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
HPA PSMB9 tissue · HPA PSMB9 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMB9" OR ABSTRACT:"PSMB9" OR TITLE:"proteasome 20S subunit beta 9" OR ABSTRACT:"proteasome 20S subunit beta 9" OR TITLE:"Proteasome subunit beta type-9" OR ABSTRACT:"Proteasome subunit beta type-9" OR TITLE:"RING12" OR ABSTRACT:"RING12" OR TITLE:"beta1i" OR ABSTRACT:"beta1i" OR TITLE:"PSMB6i" OR ABSTRACT:"PSMB6i") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMB9, not a curated reading list.