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PSMB10 (Proteasome subunit beta type-10) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.75, animal model 0.45, genetic association 0.00, clinical 0.99).
In plain words · PSMB10 (Proteasome subunit beta type-10) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMB10 (Proteasome subunit beta type-10) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
No product in this corpus aims at PSMB10 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSMB10: RNA tissue enhanced (lymphoid tissue 136 nTPM); high antibody staining in 11 normal tissues; highest cancer staining lymphoma (5 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PSMB10 tissue; Open Targets ENSG00000205220 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Larsen et al, Hum. Mol. Genet, 1993, "A tight cluster of five unrelated human genes on chromosome 16q22.1". Source.
Sources: HGNC HGNC:9538 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P40306 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205220 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.58, mantle cell lymphoma 0.54 (GraphQL API, CC0))
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Location: Cytoplasm; Nucleus (UniProt). Locus 16q22.1 (HGNC).
RNA: tissue enhanced (lymphoid tissue 136 nTPM), detected in many normal tissues.
Medium: Appendix, Bone marrow, Cerebral cortex, Colon, Endometrium, Placenta, Prostate, Skin.
Medium only: breast cancer, colorectal cancer, head and neck cancer, liver cancer.
HPA PSMB10 tissue · HPA PSMB10 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMB10" OR ABSTRACT:"PSMB10" OR TITLE:"proteasome 20S subunit beta 10" OR ABSTRACT:"proteasome 20S subunit beta 10" OR TITLE:"Proteasome subunit beta type-10" OR ABSTRACT:"Proteasome subunit beta type-10" OR TITLE:"LMP10" OR ABSTRACT:"LMP10" OR TITLE:"MGC1665" OR ABSTRACT:"MGC1665" OR TITLE:"beta2i" OR ABSTRACT:"beta2i") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMB10, not a curated reading list.