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PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.25, literature 0.97, genetic association 0.13, somatic mutation 0.87, animal model 0.25). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Gallbladder Cancer.
In plain words · PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses.
No product in this corpus aims at PSIP1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1998. Earliest sequence paper UniProt cites for the protein: Ge et al, EMBO J, 1998, "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation". Source.
Sources: HGNC HGNC:9527 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75475 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164985 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.51, urinary bladder cancer 0.51 (GraphQL API, CC0)); IntOGen PSIP1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Location: Nucleus (UniProt). Locus 9p22.3 (HGNC).
Query for this target: (TITLE:"PSIP1" OR ABSTRACT:"PSIP1" OR TITLE:"PC4 and SRSF1 interacting protein 1" OR ABSTRACT:"PC4 and SRSF1 interacting protein 1" OR TITLE:"PC4 and SFRS1-interacting protein" OR ABSTRACT:"PC4 and SFRS1-interacting protein" OR TITLE:"p52" OR ABSTRACT:"p52" OR TITLE:"LEDGF" OR ABSTRACT:"LEDGF" OR TITLE:"p75" OR ABSTRACT:"p75") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSIP1, not a curated reading list.
Shares Menin / KMT2A (HOXA9-MEIS1 axis), IntOGen.