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PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.89, genetic association 0.00).
In plain words · PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation.
No product in this corpus aims at PPP2R5B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: McCright et al, J. Biol. Chem, 1995, "Identification of a new family of protein phosphatase 2A regulatory subunits". Source.
Sources: HGNC HGNC:9310 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15173 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000068971 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Location: Cytoplasm (UniProt). Locus 11q13.1 (HGNC).
Query for this target: (TITLE:"PPP2R5B" OR ABSTRACT:"PPP2R5B" OR TITLE:"protein phosphatase 2 regulatory subunit B'beta" OR ABSTRACT:"protein phosphatase 2 regulatory subunit B'beta" OR TITLE:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform" OR TITLE:"FLJ35411" OR ABSTRACT:"FLJ35411" OR TITLE:"B56B" OR ABSTRACT:"B56B" OR TITLE:"PR61B" OR ABSTRACT:"PR61B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R5B, not a curated reading list.