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PPP2R5A (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.69, affected pathway 0.89, animal model 0.62, genetic association 0.19).
In plain words · PPP2R5A (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PPP2R5A (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment.
No product in this corpus aims at PPP2R5A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: McCright et al, J. Biol. Chem, 1995, "Identification of a new family of protein phosphatase 2A regulatory subunits". Source.
Sources: HGNC HGNC:9309 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15172 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000066027 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. Location: Cytoplasm; Nucleus; Chromosome, centromere (UniProt). Locus 1q32.3 (HGNC).
Query for this target: (TITLE:"PPP2R5A" OR ABSTRACT:"PPP2R5A" OR TITLE:"protein phosphatase 2 regulatory subunit B'alpha" OR ABSTRACT:"protein phosphatase 2 regulatory subunit B'alpha" OR TITLE:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform" OR TITLE:"PR61A" OR ABSTRACT:"PR61A" OR TITLE:"B56A" OR ABSTRACT:"B56A" OR TITLE:"B56alpha" OR ABSTRACT:"B56alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R5A, not a curated reading list.