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PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib and PARP Inhibitor ABT-888.
In plain words · PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67.
No product in this corpus aims at PPP2R2A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PPP2R2A: RNA low tissue specificity; high antibody staining in 12 normal tissues; highest cancer staining melanoma (3 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PPP2R2A tissue; Open Targets ENSG00000221914 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Mayer R.E. et al, Biochemistry, 1991, "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Source.
Sources: HGNC HGNC:9304 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P63151 (protein name, function text, keywords and locations (REST API)); CIViC gene PPP2R2A (2 evidence items, 0 assertions, 2 variants; diseases: Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0))
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Locus 8p21.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Appendix, Cerebral cortex, Cervix, Colon, Esophagus, Gallbladder, Hippocampus, Kidney.
Medium only: cervical cancer, endometrial cancer, head and neck cancer, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PPP2R2A" OR ABSTRACT:"PPP2R2A" OR TITLE:"protein phosphatase 2 regulatory subunit Balpha" OR ABSTRACT:"protein phosphatase 2 regulatory subunit Balpha" OR TITLE:"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform" OR TITLE:"PR52A" OR ABSTRACT:"PR52A" OR TITLE:"PR55A" OR ABSTRACT:"PR55A" OR TITLE:"B55A" OR ABSTRACT:"B55A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R2A, not a curated reading list.