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PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.89, genetic association 0.51, somatic mutation 0.55).
In plain words · PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).
No product in this corpus aims at PPP2R1B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1990. Earliest sequence paper UniProt cites for the protein: Hemmings B.A. et al, Biochemistry, 1990, "Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Source.
Sources: HGNC HGNC:9303 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30154 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137713 (association with cancer (MONDO_0004992) 0.68; (GraphQL API, CC0))
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).
Query for this target: (TITLE:"PPP2R1B" OR ABSTRACT:"PPP2R1B" OR TITLE:"protein phosphatase 2 scaffold subunit Abeta" OR ABSTRACT:"protein phosphatase 2 scaffold subunit Abeta" OR TITLE:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform" OR TITLE:"PR65B" OR ABSTRACT:"PR65B" OR TITLE:"PP2A-Abeta" OR ABSTRACT:"PP2A-Abeta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R1B, not a curated reading list.