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PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.89, literature 0.38, genetic association 0.03, animal model 0.47).
In plain words · PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events.
No product in this corpus aims at PPP2CB yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PPP2CB: RNA low tissue specificity; high antibody staining in 22 normal tissues; highest cancer staining glioma (2 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PPP2CB tissue; Open Targets ENSG00000104695 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Hemmings B.A. et al, Nucleic Acids Res, 1988, "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit". Source.
Sources: HGNC HGNC:9300 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62714 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104695 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 8p12 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Breast, Cervix, Endometrium, Epididymis, Fallopian tube, Liver, Lung.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PPP2CB" OR ABSTRACT:"PPP2CB" OR TITLE:"protein phosphatase 2 catalytic subunit beta" OR ABSTRACT:"protein phosphatase 2 catalytic subunit beta" OR TITLE:"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform" OR TITLE:"PP2Abeta" OR ABSTRACT:"PP2Abeta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2CB, not a curated reading list.