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PPP2CA (Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.78, literature 0.87, genetic association 0.00, somatic mutation 0.23).
In plain words · PPP2CA (Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
PPP2CA (Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events.
No product in this corpus aims at PPP2CA yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists PPP2CA among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PPP2CA: RNA low tissue specificity; no normal tissue stained high; highest cancer staining glioma (2 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PPP2CA tissue; Open Targets ENSG00000113575 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Stone S.R. et al, Nucleic Acids Res, 1988, "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit". Source.
Sources: HGNC HGNC:9299 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P67775 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113575 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Location: Cytoplasm; Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 5q31.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high; medium in Adrenal gland, Appendix, Breast, Bronchus, Caudate, Cerebellum and more.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
HPA PPP2CA tissue · HPA PPP2CA pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PPP2CA" OR ABSTRACT:"PPP2CA" OR TITLE:"protein phosphatase 2 catalytic subunit alpha" OR ABSTRACT:"protein phosphatase 2 catalytic subunit alpha" OR TITLE:"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform" OR TITLE:"PP2Calpha" OR ABSTRACT:"PP2Calpha" OR TITLE:"PP2AC" OR ABSTRACT:"PP2AC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2CA, not a curated reading list.