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PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.74).
In plain words · PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
No product in this corpus aims at PPP1R14A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Cui W.C. et al, 1999, "Cloning a new human cDNA homologous to Sus scrofa mRNA for 17-KDa PKC-potentiated inhibitory protein of PP1". Source.
Sources: HGNC HGNC:14871 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96A00 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167641 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0))
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Location: Cytoplasm (UniProt). Locus 19q13.1 (HGNC).
Query for this target: (TITLE:"PPP1R14A" OR ABSTRACT:"PPP1R14A" OR TITLE:"protein phosphatase 1 regulatory inhibitor subunit 14A" OR ABSTRACT:"protein phosphatase 1 regulatory inhibitor subunit 14A" OR TITLE:"Protein phosphatase 1 regulatory subunit 14A" OR ABSTRACT:"Protein phosphatase 1 regulatory subunit 14A" OR TITLE:"CPI-17" OR ABSTRACT:"CPI-17" OR TITLE:"PPP1INL" OR ABSTRACT:"PPP1INL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP1R14A, not a curated reading list.