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PPM1B (Protein phosphatase 1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.78, affected pathway 0.83, genetic association 0.00).
In plain words · PPM1B (Protein phosphatase 1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
PPM1B (Protein phosphatase 1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.
No product in this corpus aims at PPM1B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1998. Earliest sequence paper UniProt cites for the protein: Marely A.E. et al, FEBS Lett, 1998, "The cloning expression and tissue distribution of human PP2Cbeta". Source.
Sources: HGNC HGNC:9276 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75688 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138032 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signalling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Location: Cytoplasm, cytosol; Membrane (UniProt). Locus 2p21 (HGNC).
Query for this target: (TITLE:"PPM1B" OR ABSTRACT:"PPM1B" OR TITLE:"protein phosphatase, Mg2+/Mn2+ dependent 1B" OR ABSTRACT:"protein phosphatase, Mg2+/Mn2+ dependent 1B" OR TITLE:"Protein phosphatase 1B" OR ABSTRACT:"Protein phosphatase 1B" OR TITLE:"PPC2BETAX" OR ABSTRACT:"PPC2BETAX" OR TITLE:"PP2CB" OR ABSTRACT:"PP2CB" OR TITLE:"PP2CBETA" OR ABSTRACT:"PP2CBETA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPM1B, not a curated reading list.