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PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.76, genetic association 0.04, somatic mutation 0.65).
In plain words · PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
No product in this corpus aims at PPFIBP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Serra-Pages et al, J. Biol. Chem, 1998, "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". Source.
Sources: HGNC HGNC:9249 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86W92 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110841 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Location: Cytoplasm, cell cortex (UniProt). Locus 12p11.23-p11.22 (HGNC).
Query for this target: (TITLE:"PPFIBP1" OR ABSTRACT:"PPFIBP1" OR TITLE:"PPFIB scaffold protein 1" OR ABSTRACT:"PPFIB scaffold protein 1" OR TITLE:"Liprin-beta-1" OR ABSTRACT:"Liprin-beta-1" OR TITLE:"L2" OR ABSTRACT:"L2" OR TITLE:"hSGT2" OR ABSTRACT:"hSGT2" OR TITLE:"hSgt2p" OR ABSTRACT:"hSgt2p") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPFIBP1, not a curated reading list.