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POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
Shows weak transcriptional activator activity.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.85).
In plain words · POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt).
No product in this corpus aims at POU5F1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1992. Earliest sequence paper UniProt cites for the protein: Takeda et al, Nucleic Acids Res, 1992, "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues". Source.
Sources: HGNC HGNC:9223 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06416 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000212993 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.56, prostate cancer 0.64 (GraphQL API, CC0))
Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt). Locus 8q24.21 (HGNC).
Query for this target: (TITLE:"POU5F1B" OR ABSTRACT:"POU5F1B" OR TITLE:"POU class 5 homeobox 1B" OR ABSTRACT:"POU class 5 homeobox 1B" OR TITLE:"POU domain, class 5, transcription factor 1B" OR ABSTRACT:"POU domain, class 5, transcription factor 1B" OR TITLE:"OTF3C" OR ABSTRACT:"OTF3C" OR TITLE:"OTF3P1" OR ABSTRACT:"OTF3P1" OR TITLE:"POU5F1P1" OR ABSTRACT:"POU5F1P1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POU5F1B, not a curated reading list.