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POGLUT3 (Protein O-glucosyltransferase 3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Protein glucosyltransferase that catalyses the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyse the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.71).
In plain words · POGLUT3 (Protein O-glucosyltransferase 3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
POGLUT3 (Protein O-glucosyltransferase 3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Protein glucosyltransferase that catalyses the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C.
No product in this corpus aims at POGLUT3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2002. Earliest sequence paper UniProt cites for the protein: Ding et al, 2002. Source.
Sources: HGNC HGNC:28496 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z4H8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178202 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Protein glucosyltransferase that catalyses the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyse the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signalling pathway. Location: Endoplasmic reticulum lumen (UniProt). Locus 11q22.3 (HGNC).
Query for this target: (TITLE:"POGLUT3" OR ABSTRACT:"POGLUT3" OR TITLE:"protein O-glucosyltransferase 3" OR ABSTRACT:"protein O-glucosyltransferase 3" OR TITLE:"Protein O-glucosyltransferase 3" OR ABSTRACT:"Protein O-glucosyltransferase 3" OR TITLE:"MGC33424" OR ABSTRACT:"MGC33424" OR TITLE:"KDELC2" OR ABSTRACT:"KDELC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POGLUT3, not a curated reading list.