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PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Probably involved in the repair of mismatches in DNA.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.76, somatic mutation 0.50, genetic literature 0.01).
In plain words · PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt).
No product in this corpus aims at PMS1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Nicolaides N.C. et al, Nature, 1994, "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer". Source.
Sources: HGNC HGNC:9121 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P54277 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000064933 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0))
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 2q32.2 (HGNC).
Query for this target: (TITLE:"PMS1" OR ABSTRACT:"PMS1" OR TITLE:"PMS1 homolog 1, mismatch repair system component" OR ABSTRACT:"PMS1 homolog 1, mismatch repair system component" OR TITLE:"PMS1 protein homolog 1" OR ABSTRACT:"PMS1 protein homolog 1" OR TITLE:"MLH2" OR ABSTRACT:"MLH2" OR TITLE:"PMSL1" OR ABSTRACT:"PMSL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PMS1, not a curated reading list.