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PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.93, animal model 0.55, genetic association 0.66).
In plain words · PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development.
No product in this corpus aims at PLXNB2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:9104 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15031 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196576 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Location: Cell membrane (UniProt). Locus 22q13.33 (HGNC).
Query for this target: (TITLE:"PLXNB2" OR ABSTRACT:"PLXNB2" OR TITLE:"plexin B2" OR ABSTRACT:"plexin B2" OR TITLE:"Plexin-B2" OR ABSTRACT:"Plexin-B2" OR TITLE:"MM1" OR ABSTRACT:"MM1" OR TITLE:"KIAA0315" OR ABSTRACT:"KIAA0315" OR TITLE:"PLEXB2" OR ABSTRACT:"PLEXB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLXNB2, not a curated reading list.