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PER1 (Period circadian protein homolog 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behaviour. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98).
In plain words · PER1 (Period circadian protein homolog 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
PER1 (Period circadian protein homolog 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
Transcriptional repressor which forms a core component of the circadian clock.
No product in this corpus aims at PER1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Sun Z.S. et al, Cell, 1997, "Rigui, a putative mammalian ortholog of the Drosophila period gene". Source.
Sources: HGNC HGNC:8845 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15534 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179094 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.50, gastric cancer 0.51, melanoma 0.56, skin cancer 0.56, lung cancer 0.53 (GraphQL API, CC0))
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behaviour. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. Location: Nucleus; Cytoplasm (UniProt). Locus 17p13.1 (HGNC).
Query for this target: (TITLE:"PER1" OR ABSTRACT:"PER1" OR TITLE:"period circadian regulator 1" OR ABSTRACT:"period circadian regulator 1" OR TITLE:"Period circadian protein homolog 1" OR ABSTRACT:"Period circadian protein homolog 1" OR TITLE:"RIGUI" OR ABSTRACT:"RIGUI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PER1, not a curated reading list.