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PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.64).
In plain words · PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion.
No product in this corpus aims at PDLIM5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Ueki et al, J. Hum. Genet, 1999, "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)". Source.
Sources: HGNC HGNC:17468 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96HC4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163110 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Location: Postsynaptic density; Presynapse; Postsynapse; Cytoplasm, cytosol (UniProt). Locus 4q22.3 (HGNC).
Query for this target: (TITLE:"PDLIM5" OR ABSTRACT:"PDLIM5" OR TITLE:"PDZ and LIM domain 5" OR ABSTRACT:"PDZ and LIM domain 5" OR TITLE:"PDZ and LIM domain protein 5" OR ABSTRACT:"PDZ and LIM domain protein 5" OR TITLE:"Enh" OR ABSTRACT:"Enh") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDLIM5, not a curated reading list.