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PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like".
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.30, genetic association 0.47, somatic mutation 0.55, animal model 0.43).
In plain words · PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like". Location: Secreted (UniProt).
No product in this corpus aims at PDGFRL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Fujiwara et al, Oncogene, 1995, "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene". Source.
Sources: HGNC HGNC:8805 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15198 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104213 (association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0))
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like". Location: Secreted (UniProt). Locus 8p22 (HGNC).
Query for this target: (TITLE:"PDGFRL" OR ABSTRACT:"PDGFRL" OR TITLE:"platelet derived growth factor receptor like" OR ABSTRACT:"platelet derived growth factor receptor like" OR TITLE:"Platelet-derived growth factor receptor-like protein" OR ABSTRACT:"Platelet-derived growth factor receptor-like protein" OR TITLE:"PRLTS" OR ABSTRACT:"PRLTS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDGFRL, not a curated reading list.