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PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.63, animal model 0.52, genetic association 0.64).
In plain words · PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt).
No product in this corpus aims at PCNX2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:8736 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NKB5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135749 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt). Locus 1q42.2 (HGNC).
Query for this target: (TITLE:"PCNX2" OR ABSTRACT:"PCNX2" OR TITLE:"pecanex 2" OR ABSTRACT:"pecanex 2" OR TITLE:"Pecanex-like protein 2" OR ABSTRACT:"Pecanex-like protein 2" OR TITLE:"KIAA0435" OR ABSTRACT:"KIAA0435" OR TITLE:"FLJ11383" OR ABSTRACT:"FLJ11383" OR TITLE:"PCNXL2" OR ABSTRACT:"PCNXL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCNX2, not a curated reading list.