Loading
PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.46, somatic mutation 0.74). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme.
In plain words · PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2.
No product in this corpus aims at PCM1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1994. Earliest sequence paper UniProt cites for the protein: Balczon et al, J. Cell Biol, 1994, "PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution". Source.
Sources: HGNC HGNC:8727 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15154 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078674 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0)); IntOGen PCM1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic granule; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite (UniProt). Locus 8p22 (HGNC).
Query for this target: (TITLE:"PCM1" OR ABSTRACT:"PCM1" OR TITLE:"pericentriolar material 1" OR ABSTRACT:"pericentriolar material 1" OR TITLE:"Pericentriolar material 1 protein" OR ABSTRACT:"Pericentriolar material 1 protein" OR TITLE:"PTC4" OR ABSTRACT:"PTC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCM1, not a curated reading list.