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PBLD (Phenazine biosynthesis-like domain-containing protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signalling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · PBLD (Phenazine biosynthesis-like domain-containing protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
PBLD (Phenazine biosynthesis-like domain-containing protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signalling via multiple pathways.
No product in this corpus aims at PBLD yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PBLD: RNA group enriched (intestine 161 nTPM, kidney 252 nTPM, liver 313 nTPM); high antibody staining in 4 normal tissues; highest cancer staining renal cancer (3 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PBLD tissue; Open Targets ENSG00000108187 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Hochstrasser D.F. et al, Electrophoresis, 1992, "Human liver protein map: a reference database established by microsequencing and gel comparison". Source.
Sources: HGNC HGNC:23301 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30039 (protein name, function text, keywords and locations (REST API)); CIViC gene PBLD (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signalling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication. Up-regulates IFN-I response by activating the NF-kappaB signalling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. Additionally, promotes the p53-USP4-MAVS signalling axis by stabilising MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection. Acts as a tumour suppressor, regulating development of various cancers. Locus 10q21.3 (HGNC).
RNA: group enriched (intestine 161 nTPM, kidney 252 nTPM, liver 313 nTPM), detected in all normal tissues.
Medium: Appendix, Colon, Liver, Rectum, Small intestine, Stomach.
Medium only: cervical cancer, liver cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PBLD" OR ABSTRACT:"PBLD" OR TITLE:"phenazine biosynthesis like protein domain containing" OR ABSTRACT:"phenazine biosynthesis like protein domain containing" OR TITLE:"Phenazine biosynthesis-like domain-containing protein" OR ABSTRACT:"Phenazine biosynthesis-like domain-containing protein" OR TITLE:"MAWBP" OR ABSTRACT:"MAWBP" OR TITLE:"MAWDBP" OR ABSTRACT:"MAWDBP" OR TITLE:"FLJ14767" OR ABSTRACT:"FLJ14767") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PBLD, not a curated reading list.