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PAX9 (Paired box protein Pax-9) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.48, genetic association 0.65).
In plain words · PAX9 (Paired box protein Pax-9) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
PAX9 (Paired box protein Pax-9) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Location: Nucleus (UniProt).
No product in this corpus aims at PAX9 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1993. Earliest sequence paper UniProt cites for the protein: Stapleton et al, Nat. Genet, 1993, "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Source.
Sources: HGNC HGNC:8623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55771 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198807 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Location: Nucleus (UniProt). Locus 14q13.3 (HGNC).
Query for this target: (TITLE:"PAX9" OR ABSTRACT:"PAX9" OR TITLE:"paired box 9" OR ABSTRACT:"paired box 9" OR TITLE:"Paired box protein Pax-9" OR ABSTRACT:"Paired box protein Pax-9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX9, not a curated reading list.