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PAX6 (Paired box protein Pax-6) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters.
Open Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes literature 0.98, animal model 0.87, genetic association 0.89, genetic literature 0.89).
In plain words · PAX6 (Paired box protein Pax-6) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
PAX6 (Paired box protein Pax-6) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells.
No product in this corpus aims at PAX6 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: Ton C.C.T. et al, Cell, 1991, "Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region". Source.
Sources: HGNC HGNC:8620 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P26367 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000007372 (association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: renal cell carcinoma 0.82 (GraphQL API, CC0))
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. Location: Nucleus (UniProt). Locus 11p13 (HGNC).
Query for this target: (TITLE:"PAX6" OR ABSTRACT:"PAX6" OR TITLE:"paired box 6" OR ABSTRACT:"paired box 6" OR TITLE:"Paired box protein Pax-6" OR ABSTRACT:"Paired box protein Pax-6" OR TITLE:"D11S812E" OR ABSTRACT:"D11S812E" OR TITLE:"AN1" OR ABSTRACT:"AN1" OR TITLE:"AN2" OR ABSTRACT:"AN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX6, not a curated reading list.