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OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.93, animal model 0.57, genetic association 0.73).
In plain words · OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
No product in this corpus aims at OTX1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1993. Earliest sequence paper UniProt cites for the protein: Simeone et al, EMBO J, 1993, "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo". Source.
Sources: HGNC HGNC:8521 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P32242 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115507 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0))
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Location: Nucleus (UniProt). Locus 2p15 (HGNC).
Query for this target: (TITLE:"OTX1" OR ABSTRACT:"OTX1" OR TITLE:"orthodenticle homeobox 1" OR ABSTRACT:"orthodenticle homeobox 1" OR TITLE:"Homeobox protein OTX1" OR ABSTRACT:"Homeobox protein OTX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OTX1, not a curated reading list.