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ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.
In plain words · ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.
No product in this corpus aims at ORC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists ORC1 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA ORC1: RNA tissue enhanced (bone marrow 27 nTPM, lymphoid tissue 11 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ORC1 tissue; Open Targets ENSG00000085840 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Gavin K.A. et al, Science, 1995, "Conserved initiator proteins in eukaryotes". Source.
Sources: HGNC HGNC:8487 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13415 (protein name, function text, keywords and locations (REST API)); CIViC gene ORC1 (1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0))
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Location: Nucleus (UniProt). Locus 1p32.3 (HGNC).
RNA: tissue enhanced (bone marrow 27 nTPM, lymphoid tissue 11 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Testicular Germ Cell Tumor 22 pTPM.
No cancer stained high; medium in breast cancer, colorectal cancer, glioma, liver cancer.
HPA ORC1 tissue · HPA ORC1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ORC1" OR ABSTRACT:"ORC1" OR TITLE:"origin recognition complex subunit 1" OR ABSTRACT:"origin recognition complex subunit 1" OR TITLE:"Origin recognition complex subunit 1" OR ABSTRACT:"Origin recognition complex subunit 1" OR TITLE:"HSORC1" OR ABSTRACT:"HSORC1" OR TITLE:"PARC1" OR ABSTRACT:"PARC1" OR TITLE:"ORC1L" OR ABSTRACT:"ORC1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ORC1, not a curated reading list.