Loading
OLIG2 (Oligodendrocyte transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.95, animal model 0.38, genetic association 0.00, somatic mutation 0.94).
In plain words · OLIG2 (Oligodendrocyte transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
OLIG2 (Oligodendrocyte transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation.
No product in this corpus aims at OLIG2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Kuroda et al, 1996, "Protein kinase C-binding protein". Source.
Sources: HGNC HGNC:9398 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13516 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205927 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.53 (GraphQL API, CC0))
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) generation through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Location: Nucleus; Cytoplasm (UniProt). Locus 21q22.11 (HGNC).
Query for this target: (TITLE:"OLIG2" OR ABSTRACT:"OLIG2" OR TITLE:"oligodendrocyte transcription factor 2" OR ABSTRACT:"oligodendrocyte transcription factor 2" OR TITLE:"Oligodendrocyte transcription factor 2" OR ABSTRACT:"Oligodendrocyte transcription factor 2" OR TITLE:"RACK17" OR ABSTRACT:"RACK17" OR TITLE:"OLIGO2" OR ABSTRACT:"OLIGO2" OR TITLE:"bHLHe19" OR ABSTRACT:"bHLHe19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OLIG2, not a curated reading list.