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NTHL1 (Endonuclease III-like protein 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.91, literature 0.93, genetic association 0.61, somatic mutation 0.49, animal model 0.47).
In plain words · NTHL1 (Endonuclease III-like protein 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
NTHL1 (Endonuclease III-like protein 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage.
No product in this corpus aims at NTHL1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1997. Earliest sequence paper UniProt cites for the protein: Hilbert T.P. et al, J. Biol. Chem, 1997, "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III". Source.
Sources: HGNC HGNC:8028 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78549 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000065057 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0))
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognises and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Location: Nucleus; Mitochondrion (UniProt). Locus 16p13.3 (HGNC).
Query for this target: (TITLE:"NTHL1" OR ABSTRACT:"NTHL1" OR TITLE:"nth like DNA glycosylase 1" OR ABSTRACT:"nth like DNA glycosylase 1" OR TITLE:"Endonuclease III-like protein 1" OR ABSTRACT:"Endonuclease III-like protein 1" OR TITLE:"NTH1" OR ABSTRACT:"NTH1" OR TITLE:"OCTS3" OR ABSTRACT:"OCTS3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NTHL1, not a curated reading list.