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NRIP1 (Nuclear receptor-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.65).
In plain words · NRIP1 (Nuclear receptor-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
NRIP1 (Nuclear receptor-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.
No product in this corpus aims at NRIP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Cavailles et al, EMBO J, 1995, "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor". Source.
Sources: HGNC HGNC:8001 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P48552 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000180530 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: breast cancer 0.52 (GraphQL API, CC0))
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. Location: Nucleus (UniProt). Locus 21q11.2-q21.1 (HGNC).
Query for this target: (TITLE:"NRIP1" OR ABSTRACT:"NRIP1" OR TITLE:"nuclear receptor interacting protein 1" OR ABSTRACT:"nuclear receptor interacting protein 1" OR TITLE:"Nuclear receptor-interacting protein 1" OR ABSTRACT:"Nuclear receptor-interacting protein 1" OR TITLE:"RIP140" OR ABSTRACT:"RIP140") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRIP1, not a curated reading list.