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NRG4 (Pro-neuregulin-4, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.95, genetic association 0.00).
In plain words · NRG4 (Pro-neuregulin-4, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
NRG4 (Pro-neuregulin-4, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
No product in this corpus aims at NRG4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:29862 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WWG1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169752 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Location: Cell membrane; Secreted (UniProt). Locus 15q24.2 (HGNC).
Query for this target: (TITLE:"NRG4" OR ABSTRACT:"NRG4" OR TITLE:"neuregulin 4" OR ABSTRACT:"neuregulin 4" OR TITLE:"Pro-neuregulin-4, membrane-bound isoform" OR ABSTRACT:"Pro-neuregulin-4, membrane-bound isoform" OR TITLE:"HRG4" OR ABSTRACT:"HRG4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRG4, not a curated reading list.