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NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.70, affected pathway 0.95, genetic association 0.53).
In plain words · NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor.
No product in this corpus aims at NRG3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Zhang et al, Proc. Natl. Acad. Sci. U.S.A, 1997, "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Source.
Sources: HGNC HGNC:7999 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56975 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185737 (association with cancer (MONDO_0004992) 0.69; (GraphQL API, CC0))
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Location: Cell membrane; Secreted (UniProt). Locus 10q23.1 (HGNC).
Query for this target: (TITLE:"NRG3" OR ABSTRACT:"NRG3" OR TITLE:"neuregulin 3" OR ABSTRACT:"neuregulin 3" OR TITLE:"Pro-neuregulin-3, membrane-bound isoform" OR ABSTRACT:"Pro-neuregulin-3, membrane-bound isoform") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRG3, not a curated reading list.