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NRG2 (Pro-neuregulin-2, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.95, genetic association 0.00).
In plain words · NRG2 (Pro-neuregulin-2, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
NRG2 (Pro-neuregulin-2, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
No product in this corpus aims at NRG2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Higashiyama et al, J. Biochem, 1997, "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4". Source.
Sources: HGNC HGNC:7998 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14511 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000158458 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor. Location: Cell membrane; Secreted (UniProt). Locus 5q31.2 (HGNC).
Query for this target: (TITLE:"NRG2" OR ABSTRACT:"NRG2" OR TITLE:"neuregulin 2" OR ABSTRACT:"neuregulin 2" OR TITLE:"Pro-neuregulin-2, membrane-bound isoform" OR ABSTRACT:"Pro-neuregulin-2, membrane-bound isoform" OR TITLE:"Don-1" OR ABSTRACT:"Don-1" OR TITLE:"HRG2" OR ABSTRACT:"HRG2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRG2, not a curated reading list.